Protein splicing and its evolution in eukaryotes

Genome and protein evolution in eukaryotes.

The past year has seen the completion of the genome sequence of the flowering plant Arabidopsis thaliana and the initial sequence reports of the human genome. The availability of completely sequenced eukaryotic genomes from disparate phylogenetic lineages has opened the door to comparative analyses and a better understanding of the evolutionary processes shaping genomes. Complex many-to-many re...

Evolution of protein domain promiscuity in eukaryotes.

Numerous eukaryotic proteins contain multiple domains. Certain domains show a tendency to occur in diverse domain architectures and can be considered "promiscuous." These promiscuous domains are, typically, involved in protein-protein interactions and play crucial roles in interaction networks, particularly those that contribute to signal transduction. A systematic comparative-genomic analysis ...

Evolution of DNA Replication Protein Complexes in Eukaryotes and Archaea

BACKGROUND The replication of DNA in Archaea and eukaryotes requires several ancillary complexes, including proliferating cell nuclear antigen (PCNA), replication factor C (RFC), and the minichromosome maintenance (MCM) complex. Bacterial DNA replication utilizes comparable proteins, but these are distantly related phylogenetically to their archaeal and eukaryotic counterparts at best. METHOD...

Sex and Evolution in Eukaryotes

Comparison of Alternative Splicing Structures in Eukaryotes

Numerous databases of alternative splice forms have been generated over the recent years, which – beside of using heterogenous input data – differ substantially in the definition and in the representation of patterns. Motivated by this, we have developed a novel relative position notation system to univocally describe alternative splicing (AS) events, and a parsing and visualization tool (AStaL...